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Development of the Nervous System presents a broad and basic treatment of the established and evolving principles of neural development as exemplified by key experiments and observations from past and recent times. The text is organized ontogenically. It begins with the emergence of the neural primordium and takes a chapter-by-chapter approach in succeeding events in neural development: patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, neuron survival and death, synapse formation and developmental plasticity.
Finally, in the last chapter, with the construction phase nearing completion, we examine the emergence of behavior. This new edition reflects the complete modernization of the field that has been achieved through the intensive application of molecular, genetic, and cell biological approaches. It is richly illustrated with color photographs and original drawings.
Combined with the clear and concise writing, the illustrations make this a book that is well suited to students approaching this intriguing field for the first time. Key Features. Dedication Preface to the Third Edition Preface to the Second Edition Preface to the First Edition 1.
The Professional Kitchen Manager Pdf Converter. Neural induction Development and evolution of neurons Early embryology of metazoans Derivation of neural tissue Interactions with neighboring tissues in making neural tissue The molecular nature of the neural inducer Conservation of neural induction Interactions among the ectodermal cells in controlling neuroblast segregation Summary 2. Polarity and segmentation Regional identity of the nervous system The anterior–posterior axis and hox genes Hox gene function in the vertebrate nervous system Signaling molecules that pattern the anterior–posterior axis in vertebrates: heads or tails Organizing centers in the developing brain Forebrain development, prosomeres, and pax genes Dorsal–ventral polarity in the neural tube Dorsal neural tube and neural crest Patterning the cerebral cortex Summary 3. Genesis and migration What determines the number of cells produced by the progenitors? The generation of neurons and glia Cerebral cortex histogenesis Cerebellar cortex histogenesis Molecular mechanisms of neuronal migration Postembryonic and adult neurogenesis Summary 4. Determination and differentiation Transcriptional hierarchies in invariant lineages: C.
Elegans neurons Spatial and temporal coordinates of determination: drosophila CNS neuroblasts Asymmetric cell divisions and asymmetric fate Generating complexity through cellular interactions: the drosophila retina Specification and differentiation through cellular interactions and interactions with the local environment: the vertebrate neural crest Competence and histogenesis: the mammalian cortex The interplay of intrinsic and extrinsic influences in histogenesis: the vertebrate retina Interpreting gradients and the spatial organization of cell types: spinal motor neurons Summary 5. Axon growth and guidance The growth cone The dynamic cytoskeleton Dendrite formation What do growth cones grow on? What provides directional information to growth cones? Cell adhesion and labeled pathways Repulsive guidance Chemotaxis, gradients, and local information Signal transduction The midline: to cross or not to cross? Attraction and repulsion: desensitization and adaptation The optic pathway: getting there from here Summary 6. Target selection Defasciculation Target recognition and target entry Slowing down and branching in the target region Border patrol: the prevention of inappropriate targeting Topographic mapping Chemospecificity and ephrins The third dimension, lamina-specific termination Cellular and synaptic targeting Sniffing out targets Shifting and fine tuning of connections Summary 7.
Naturally-occurring neuron death What does neuron death look like? Early elimination of progenitor cells How many differentiated neurons die? Survival depends on the synaptic target NGF: a target-derived survival factor The neurotrophin family The trk family of neurotrophin receptors How does the neurotrophin signal reach the soma? The p75 neurotrophin receptor can initiate cell death Cytokines act as neuron survival factors Hormonal control of neuron survival Cell death requires protein synthesis Intracellular signaling pathways that mediate survival Intracellular signaling pathways that mediate death Caspases: agents of death Bcl-2 proteins: regulators of programmed cell death Removal of dying neurons Synaptic transmission at the target Afferent regulation of neuron survival Intracellular calcium mediates both survival and death Summary 8. Synapse formation and function What do newly formed synapses look like? Where Do Synapses Form on the Postsynaptic Cell?
How Rapidly Are Synapses Added to the Nervous System? Reh is Professor of Biological Structure and Director of the Neurobiology and Behavior Program at the University of Washington. He is currently a member of the Scientific Advisory Board of the Foundation Fighting Blindness, and of a start-up biotechnology company, Acucela. He has received several awards for his work, including the AHFMR and Sloan Scholar awards and has published over 100 journal articles, reviews and books. Funded by numerous N.I.H. And private foundation grants, his lab is focused on the development and repair of the retina, with an overall goal of understanding the cellular and molecular biology of regeneration in the eye. Harris is co-chair of Cambridge Neuroscience and Director of Studies in Neuroscience.
He is also Head of the Department of Physiology, Development, and Neuroscience, and is Professor of Anatomy. Elected a Fellow of the Royal Society of London in 2007, he was Professor of Biology at UCSD prior to accepting a position at Cambridge. His lab is working to elucidate the cellular and molecular events that are used to push or induce cells to transition from proliferating stem cells to differentiated neurons and glia, and how particular regions of the nervous system produce the right number of neurons and the right proportions of different neuron subtypes. Sanes is Professor in the Center for Neural Science and Department of Biology at New York University. Named a Fellow of the American Association for the Advancement of Science (AAAS) in 2010 for his research in auditory central nervous system development, his research has been supported by the National Institute on Deafness and Other Communication Disorders and the National Science Foundation.
His lab studies synaptic plasticity and central auditory processing, and the phenomenon of hearing loss during development. Reh is Professor of Biological Structure and Director of the Neurobiology and Behavior Program at the University of Washington.
He is currently a member of the Scientific Advisory Board of the Foundation Fighting Blindness, and of a start-up biotechnology company, Acucela. He has received several awards for his work, including the AHFMR and Sloan Scholar awards and has published over 100 journal articles, reviews and books. Funded by numerous N.I.H.
And private foundation grants, his lab is focused on the development and repair of the retina, with an overall goal of understanding the cellular and molecular biology of regeneration in the eye. Harris is co-chair of Cambridge Neuroscience and Director of Studies in Neuroscience. Jensen Xa 1120 Manual Dexterity. He is also Head of the Department of Physiology, Development, and Neuroscience, and is Professor of Anatomy. Elected a Fellow of the Royal Society of London in 2007, he was Professor of Biology at UCSD prior to accepting a position at Cambridge.
His lab is working to elucidate the cellular and molecular events that are used to push or induce cells to transition from proliferating stem cells to differentiated neurons and glia, and how particular regions of the nervous system produce the right number of neurons and the right proportions of different neuron subtypes.